What Is Azor (Amlodipine and Olmesartan)?
Azor is the brand name of a combination drug that contains amlodipine and olmesartan. It's a prescription medicine used to treat high blood pressure.
Amlodipine belongs to a class of drugs called calcium channel blockers. It works by relaxing muscles in the heart and around blood vessels.
Olmesartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by stopping blood vessels from narrowing.
The U.S. Food and Drug Administration (FDA) approved Azor in 2007. It's manufactured by Daiichi Sankyo, Inc.
Before taking Azor, tell your doctor if you have, or have ever had:
Older adults may be more sensitive to certain side effects of Azor. Ask your doctor about these side effects and your risks.
You may feel dizzy if you get up too quickly from a sitting or lying position while taking this medicine. Try to get up slowly and steadily, to reduce your risk of falling.
Tell your doctor if you experience prolonged sweating, diarrhea, or vomiting while taking Azor. These may be signs of very low blood pressure, and they could indicate a high risk of becoming dehydrated.
Don't use any potassium supplements or salt substitutes while taking Azor, unless your doctor tells you to do so.
Let your doctor know if you take another medicine that contains aliskiren (such as Amturnide, Tekturna, Tekamlo, or Valturna) before taking Azor.
In rare cases, Azor can cause a condition that leads to kidney failure. Tell your doctor right away if you experience any of the following symptoms:
- Muscle pain, weakness, or tenderness (especially if you also have a fever)
- Nausea or vomiting
- Dark-colored urine
Let your healthcare provider know you're taking this medicine before having any type of surgery, including a dental procedure.
Continue to take Azor even if you feel well. Don't stop taking this medicine without first talking to your healthcare provider.
Your doctor will want to check your blood pressure and kidney function often while you take Azor. Keep all appointments with your doctor's office and laboratory.
Pregnancy and Azor
Azor contains a black box warning because it can harm an unborn baby.
Don't take this medicine if you're pregnant or might become pregnant.
Use an effective method of birth control while taking Azor. Tell your doctor right away if you become pregnant while taking this drug.
It's not known whether Azor passes into breast milk or could hurt a breastfeeding baby.
Don't breastfeed while taking this medicine without talking to your doctor first.
Azor Side Effects
Common Side Effects of Azor
Tell your doctor if any of the following side effects become severe or don't go away:
- Mild dizziness
- Hair loss
- Mild itching or skin rash
Serious Side Effects of Azor
Call your doctor immediately if you experience any of the symptoms listed in the Azor Warnings section above, or any of the following serious side effects:
- Swelling in your hands or feet
- Rapid weight gain or weight loss
- Little or no urination
- Pounding heartbeat or fluttering in your chest
- Chest pain, or a heavy feeling spreading from the chest to the arm or shoulder
- Feeling like you might pass out
- Yellowing of the skin or eyes
- Signs of an allergic reaction (may include hives, rash, itching, chest tightness, or swelling of the face, lips, tongue, or throat)
- Elevated potassium levels
Tell your doctor about all prescription, nonprescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those listed in the Azor Warnings section above, and any of the following:
Azor and Other Interactions
Azor may make you dizzy. Don't drive or perform activities that require alertness until you know how this medicine affects you.
Azor and Alcohol
Alcohol may worsen certain side effects of Azor. Talk to your doctor before drinking alcohol while taking this medicine.
Azor comes as a tablet to take by mouth once a day, with or without food.
Your dose will depend on your medical condition and response to treatment.
Follow the instructions on your prescription label carefully. Don't take more or less Azor than is recommended.
Try to take this drug around the same time each day.
Symptoms of an Azor overdose may include severe dizziness or fainting.
If you suspect an overdose, contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at 800-222-1222.
Missed Dose of Azor
If you miss a dose of Azor, take it as soon as you remember.
But if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular medication schedule.
Don't take extra medicine to make up for a missed dose.
Q: What is the best time of day to take Azor, and should I take it with food?
A: Azor can be taken with or without food, it all depends on if you experience stomach upset with the medication. Also, Azor can be taken any time during the day, but it must be taken at the same time each day in order to keep the medication levels steady in your body.
Q: Can the drug Azor for high blood pressure be the cause of my urinating five to six times a day?
A: Azor is a combination of amlodipine and olmesartan. Amlodipine is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels. Olmesartan is in a group of drugs called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. The combination of amlodipine and olmesartan is used to treat high blood pressure (hypertension). This medication is usually given after others have been tried without successful treatment of hypertension. According to the manufacturer of Azor, urinating more often or excessive urination throughout the night was reported by patients participating in clinical trials. These side effects occurred at about the same rate as in patients taking placebo (a sugar pill). So, it's unclear if Azor actually causes this side effect or if it is related to something else. If this side effect becomes severe or bothersome to you, talk to your doctor to discuss your options. Do not stop or change the amount of medication you take without talking to your doctor first. Common side effects of Azor include dizziness; drowsiness; warmth, redness, or tingly feeling under your skin; vomiting; muscle pain or weakness; or itching, rash, or hair loss. Serious side effects can occur. Call your doctor at once if you have swelling in your hands or feet, rapid weight gain, fast or pounding heartbeats, jaundice (yellowing of the skin or eyes), chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling, or if you feel like you might pass out. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah McKenney Lewis, RPh
Q: I take the drug Azor. I understand it is a combination drug for hypertension. The copay for this drug seems like it is higher than taking the two drugs it replaces. Is the benefit worth the extra price I have to pay for this drug?
A: Azor is a combination of two medications prescribed in combination with a heart healthy lifestyle for the treatment of hypertension. Azor is a combination of Norvasc (amlodipine) a calcium channel blocker and Benicar (olmesartan) an angiotensin recepter antagonist. Norvasc is currently available as a generic drug (amlodipine) which is available at a much lower price than the brand Norvasc. Benicar does not currently have a generic alternative available. Generic drugs are lower-cost alternatives to more expensive brand-name drugs. They will appear different and have a few other minor differences from the brand-name drugs, but their labeling and directions for use must be virtually the same as that of the brand name product. Both brand-name and generic drug manufacturing facilities must follow the same standards of good manufacturing practices and meet the U.S. Food and Drug Administration
Q: Does Azor cause bleeding and softening of the gums?
A: Bleeding and softening of the gums are not specifically listed, according to the prescribing information, as a side effect of Azor (amlodipine and olmesartan). The most common side effect associated with Azor is edema (swelling). Please consult with your health care provider in regards to your symptoms for proper evaluation, diagnosis of the underlying cause and treatment options, if necessary. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.
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